Ulcerative Dermatitis Lesions in Swiss Albino Mice: A Case Report
Ashish Kumar *
Animal House Facility, All India Institute of Medical Sciences (AIIMS), Rishikesh-249 203, Uttarakhand, India.
Gyan Vardhan
Department of Pharmacology, All India Institute of Medical Sciences (AIIMS), Rishikesh-249 203, Uttarakhand, India.
Ambika Sharma *
Department of Biochemistry, College of Veterinary Science and Animal Husbandry, Mathura-281 001, Uttar Pradesh, India.
*Author to whom correspondence should be addressed.
Abstract
Aim: Ulcerative dermatitis (UD) is a common, multifactorial skin condition in laboratory mice, typically reported in C57BL/6 strains. This report documents the first known occurrence of UD in Swiss Albino mice and evaluates the response to standard topical therapy.
Presentation of the Case: Four Swiss Albino mice at the Laboratory Animal Facility, AIIMS Rishikesh, presented with alopecia, pruritus, ulcerations, anorexia, and debility. Lesions appeared on the outer pinna, dorsal thorax, and caudal areas. The mice were isolated and treated with a topical cream containing Clobetasol, Neomycin, and Miconazole, applied twice daily for five days. Only one animal recovered; the condition of the other animals deteriorated, and they were humanely euthanized.
Discussion: This case highlights Swiss Albino mice as susceptible to UD and demonstrates the limited efficacy of common topical treatments. The rapid progression may involve pruritogenic mechanisms such as mast cell degranulation. Alternative treatments like gabapentin or sodium hypochlorite may offer better outcomes in refractory cases.
Conclusion: UD requires prompt identification and intervention. Poor response to therapy often results in euthanasia due to severe morbidity. Further research is essential to develop effective treatment strategies and understand strain-specific disease dynamics.
Keywords: Ulcerative dermatitis, Swiss albino mice, multifactorial etiology, topical treatments